ghd australia IL-22_5957

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Interleukin-22

RF2-4 or IL-TIFR2), they all belong to Class Ⅱ new cytokine receptor family members. IL-22R1 as a 574aa protein, extracellular region 228aa, there are 3 N-linked glycosylation sites, signal peptide 17aa, transmembrane domain 23aa, cytoplasmic domain of 323aa, at least 8 potential phosphorylation of Tyr, which There are 4 potential STAT3 recruitment site (YXXQ motif). hlL a 10R2 as 373aa protein, can be widely expressed. It may be AK155, MDA a 7, IL for a total of 19 and Zcytol0 chain, so it is also known as receptor 2 Total chain (receptortw0cornrnonchain, R2). The combination of IL-TIF can induce two CRF2-9 chain (IL-TIF-R.) and two IL-10R2 chain (IL-hR2e) oligomerization. IL-10R! With TyK2, IL-TIF can induce Stat,, st Island and Sta% activation, IL-TIF receptor complex of the unique features is that the combination of the two chains are independent IL ~ TIF, but in IL a 10 and IFN 7 receptor complex one, only R. Chain binding ligand, R-chain is necessary for signal transduction. , Northern blot analysis, CRF2-9rntLNA in normal human tissues and human cancer cell lines in the expression: expression in normal kidney and liver to IL-22RlmlKNA, length 3.0kh; cancer cells in the test department, (1CF2-9ml ~ NA in three solid tumor cell lines (colorectal adenocarcinoma SW480, lung carcinoma A549 and melanoma G361) in expression, whereas in the former myeloid leukemia IlL a 6O,[link widoczny dla zalogowanych], epithelial carcinoma Hela, lymphoblastic leukemia MOLT-4 and in Burkitt's lymphoma Raji can not express. CRF2-9mRNA also in HepG2 liver cancer cell lines and renal cancer cell lines Caki-1 in the expression. IL-TIF in the immune system can show a variety of activities both inside and outside,[link widoczny dla zalogowanych], rat pheochromocytoma cell line (m'12) cells are used as model neurons, stimulation of IL-rrIF response, indicating that the process in its role in the neuropathology; small l0 rat mesangial cell line (MESI3) on IL-TlF also generate response, the macrophage cell lines expression of certain features,[link widoczny dla zalogowanych], including phagocytosis, inflammatory cytokine release and generation of twenty-alkane inducible NO synthase; IL-22 can promote the Thl-type response and can inhibit the Th2 cells generate m-4, so that it can be used to treat asthma, but could not inhibit production of monocyte proinflammatory cytokines, can not suppress a few of a 1O on the role of monocytes; IL-TIF as a hepatocyte stimulating factor can strongly induce SAA , n1 a antichymotrypsin and liver globulin production, indicating that it plays a role in the inflammatory process. In short, IL-22 as recently identified a novel IL may play a variety of biological functions, but there many issues need further research, such as IL-22R signal transduction in the real in what role?, with which JAK? StatI and st is how to recruit IL-TIF receptor complex on? 4 Stat whether the anchor parts If all of? socS family members (CIS and socs1 ~ S (X; S7), protein inhibitor of activated STAT (pro-teininhihitorofactivatedSTAT, PIAS) family members (PIAS-1, a 3,[link widoczny dla zalogowanych], a x and a Y) and phosphatase (SHP a 1, SHIP A 2, SHIP, PIEN and CD4) in the IL-22 signal transduction in the negative regulatory role is played? IL-22 in various physiological and pathological conditions, how the role? recombinant IL an anti-IL-22 and 22 The advent of monoclonal antibody may have broad practical applications. f l Wong Sze-chun and feeds Whipple disease Whipple disease as early as 1907 had described and defined as \, although only 1 was detected in samples of bacteria. This finding was later confirmed by the effective treatment of antibiotics, the application of electron microscopy detected in the diseased state of the bacilli single again for confirmation. many failed attempts at cultivation, 165tinNA by the proliferation and wide range of methods of molecular phylogeny of these bacteria first identified as actinomycetes, named 1h mortar mwhip-pdii. Whipple disease is a systemic disease, affecting many organ systems, resulting in abnormal prion phenomenon. This summarizes the thesis

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