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Hydrochloric acid and sodium hydroxide on guinea pig intestinal smooth muscle activity in the various segments of

,[link widoczny dla zalogowanych], Experimental pharmacology teaching and research. Chinese Journal of Hemorheology. 2005; 15 (3) 38】 upper, lower jejunum,[link widoczny dla zalogowanych], upper ileum, lower ileum of the 2cm. Will cut the quick release TyPe's intestinal fluid flush at both ends of the intestine were fixed in the ventilation tube and tension between the transducer, one set at 37 ℃ bath in Tyrode's perfusion (constant volume 50mL). Constant ventilation with continuous pump, record the activities of the normal intestinal smooth muscle as a control group,[link widoczny dla zalogowanych], and then were 0.3mL of hydrochloric acid and sodium hydroxide dropping to record changes in intestinal smooth muscle activity. After dropping a drug each,[link widoczny dla zalogowanych], with 37 ~ Tyrode's solution washed three times, to be returned to normal intestinal smooth muscle active, and then dropping the next drug. Intestinal smooth muscle by the tension transducer and Medlab bio-signal acquisition and processing system connected. Save result, all data indicated by soil s to t test was used for statistical analysis. 2 Results 2.1 The control group of isolated small intestinal smooth muscle activity in isolated small intestinal smooth muscle Yy ~ te's solution, the contraction of relatively regular and stable in the control group, the strongest of duodenal smooth muscle, jejunum, ileum smooth muscle contraction activity gradually decreased, consistent with normal physiological conditions (Table 1, Table 2). 2.2 hydrochloride on isolated smooth muscle of small intestine 0.3mL HCl group contraction of the upper duodenum and jejunum increased significantly compared with the control group there was significant difference; jejunum and ileum on the lower section of the contraction did not change significantly; The lower ileum contraction amplitude decreased compared with the control group the difference was statistically significant (Table 1). Table 1 hydrochloric acid for each segment of small intestine smooth muscle contraction (± s, g) compared with control group, * P <0.05, ** P <0.012.3 sodium hydroxide on isolated small intestinal smooth muscle of 0. 3mL sodium hydroxide obvious contraction of the duodenum, jejunum and ileum while the contraction decreased in the control group the difference was statistically significant (Table 2). Table 2 paragraphs of sodium hydroxide on small intestinal smooth muscle contraction (±, g) compared with control group, * P <0.053 discussed by hydrochloric acid secretion of gastric parietal cells, with the promotion of the decomposition and absorption of the small intestine, pancreatic juice , bile secretion. Normal gastric juice hydrochloric acid the body row of people in small intestine duodenal acidity increased, inhibition of gastric motility can be reflective. Hydrochloric acid on the small bowel, but the impact of activities inconclusive. The results showed that hydrochloric acid of the duodenum and upper jejunum spontaneous contractile activity can enhance the effect, while the contraction of the lower ileum were restrained. Acidic environment of the small intestine prompted to help the movement of the upper small intestine, is conducive to digestion and absorption of food, but the movement of the lower ileum, the significance of inhibition is not clear. Sodium hydroxide as alkaline component, is of small pancreatic ductal cells secretion and gastric acid may play a role in, for a variety of digestive enzymes in the small intestine to provide proper pH environment conducive to a variety of digestive enzymes play a role in the small intestine. But the basic mechanical components on intestinal smooth muscle contractile activity of no unified conclusion. The results showed no significant contraction of sodium hydroxide to the duodenum, while the jejunum and ileum contraction are reduced. Tip of sodium hydroxide on the guinea pig small intestinal smooth muscle activity inhibitory effect, suggesting that it may be beneficial for the food stay in the small intestine in order to facilitate the absorption of nutrients. Automatic rhythmic contraction of intestinal smooth muscle by the small intestine longitudinal muscle and circular muscle cells between the slow rhythm Caial and start L2J. Any stimulation (neurotransmitters, chemical substances, distention) on the intestinal smooth muscle slow waves are generated on the basis of the action potential, and then rise to smooth muscle contraction. Observed in the experiment had no obvious effect of hydrochloric acid and sodium hydroxide rhythm, suggesting that hydrochloric acid and sodium hydroxide on the mechanism of intestinal activity, mainly through the impact of slow waves may be generated on the basis of the number of action potentials to adjust the gastrointestinal functional status, and of slow wave rhythm may not significantly affect 【3,4 J, but the exact mechanism needs further study.

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