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Injury notes: The 49ers had no real backup plan at quarterback, so Alex Smith's separated shoulder is crippling - not that his healthy play helped much. Cornerback Tarell Brown's sprained back leaves a struggling secondary all the weaker against Denver quarterback Kyle Orton. The Broncos are so beat up,[link widoczny dla zalogowanych], they left five injured players behind when they came to London - but receiver Eddie Royal (groin) will give it a try. [link widoczny dla zalogowanych]
Broncos vs. 49ers in London

Spotlight on: Left guard [link widoczny dla zalogowanych]. The Broncos' run defense is ravaged up front by injuries. Quarterback Troy Smith may be severely limited in his first start. Running back Frank Gore loves to run behind this wide rookie. It's the only chance the offense has.