Estradiol valerate in ovariectomized rats hemorhe

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Estradiol valerate in ovariectomized rats hemorheology

Increased whole blood viscosity, and the line estradiol valerate replacement therapy, plasma viscosity and low shear rate whole blood viscosity decreases, and with the sham operation group (normal mice) differences disappear. Woodward, etc. This is similar to the results of clinical studies. The reason may be that estrogen reduced the plasma fibrinogen levels, and then the plasma and whole blood viscosity, reduced viscosity. The plasma viscosity and low shear rate whole blood viscosity under the decline, it will directly accelerate the rate of blood flow within the larger vessels, increased tissue perfusion, which may reduce cardiovascular and cerebrovascular morbidity. 3.3 The impact of red blood cells of estrogen from the body of evil experiments and previous studies found that estrogen on women's hematocrit was not obvious. Estradiol valerate possible that the number of red blood cells or plasma volume is not significantly affected. However, RBC red blood cell deformability index represents the shear rate in a variety of deformable under capacity, the greater the value, indicating that the stronger the red blood cell deformability. The viscosity of red blood cells mainly by the ratio of plasma viscosity, which increased plasma viscosity, erythrocyte deformability increased. Gelmini and other studies have found that postmenopausal women, erythrocyte deformation index was significantly lower than pre-menopausal women; and Solerte such as red blood cells of healthy women may be viral (reflecting the deformability of red blood cells) found that in 7 of the menstrual cycle days and 14 days (high estrogen levels in plasma) was significantly lower than 2l, 25 and 27 days. In this experiment, castrated rats pure red cell deformability index in each shear rate were significantly higher than the normal mice and ERT group, which may be significantly higher plasma viscosity are closely related. In short, the rats underwent ovariectomy amount of estradiol valerate replacement therapy, the nature of its rheology can be close to the level of normal mice, and rats with and without line of ERT obvious differences.

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