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Vascular endothelial growth factor and insulin-like growth factor I receptor expression in uterine leiomyoma research

A variety of cell migration into the process of providing a fiber network. The second is the induction of angiogenesis, VEGF stimulation of different sources of endothelial cell division and proliferation, and produce plasminogen activator (tissue-type, urokinase-type) and collagenase, and promote endothelial cells, monocytes and bone cell migration, conducive to the formation of blood vessels, but also conducive to tumor cell shedding into the blood vessel or to the adjacent matrix of fibrin and connective tissue proliferation, in order to create the conditions for tumor invasion and metastasis. The experimental results showed that VEGF expression in leiomyoma than in normal uterine tissue is not increased, indicating that the occurrence of VEGF in uterine fibroids, the development of leiomyoma cells play a role in modulating endothelial cell differentiation and angiogenesis,[link widoczny dla zalogowanych], which act as angiogenic growth factor, to provide blood supply to fibroid growth. VEGF expression in leiomyoma cells compared with normal uterine smooth muscle cells, the difference was not statistically significant, and uterine fibroids are benign disease, non-invasive, metastatic consistent. It has been reported, human uterine leiomyoma tissues and its receptors exist in both IGFs,[link widoczny dla zalogowanych], and IGF. Expression of IGF than 11 workers express a rich, muscular layer was significantly higher than in leiomyoma. The IGF and IGF a Ⅱ a work mainly through the combination of IGF-IR play a role. The present study, the detection of IGF-IR and found that IGF-IR expression in leiomyoma cells was significantly higher than 平滑肌 cells to support the fibroids increased synthesized in one of the reasons is to promote the growth of fibroids view 【. Rein also found that if, in cultured muscle cells and leiomyoma cells were incubated with IGF-working hours, by detecting the cell number, mitotic index and pituitary prolactin (PRL) of CentraJChinaMedicalOctober,[link widoczny dla zalogowanych], 2002, Vo1. ! Q: have found significantly higher than that of leiomyoma cells in their control group, dose-dependent manner, indicating that IGF-I via autocrine and (or) paracrine form of fibroids from the direct effect of stimulation of leiomyoma cell proliferation. Second, VEGF and IGF-IR and the mechanism of uterine fibroids uterine muscle cells derived from the Mullerian tissue differentiation and development, in normal uterine intramural still left from the more primitive embryonic Mullerian tissue generated myoblasts, and can develop into muscle cells undifferentiated mullerian tissue,[link widoczny dla zalogowanych], which by the strong potential of the cells to develop into uterine leiomyoma cells, the majority of scholars believe that interaction with a variety of factors, of which cells The role of factors have been affirmed [. The test showed that leiomyoma cells in insulin-like growth factor receptor was higher than normal incidence of smooth muscle cells to show that IGFs participate. Fujii believes that this relatively long period in the embryonic stage of the instability of undifferentiated cells in the mother accepted the role of various factors for the uterine smooth muscle proliferation and differentiation, but also accepted some of the factors which evolved into leiomyoma cells These myometrial leiomyoma cells scattered in the muscle cells and in a relatively stationary phase, when the factors that promote their growth increases, the growth of these cells to demonstrate superiority, gradually, a uterine fibroid. Basis that: VEGF and IGFs are involved in the cause of uterine fibroids. VEGF in leiomyoma growth process to provide the blood supply of the fibroids high levels of intracellular IGF-IR, and through autocrine and (or) next to the secretion of IGF-I, IGF binding a 1I, produce a series of leiomyoma cells the effects of proliferation, to promote continued growth of fibroids. Third, IGFs system to the role of ovarian steroids to occur in women of childbearing age uterine fibroids, so that the uterine leiomyoma smooth muscle tissue and also affected by ovarian hormones. Molecular biology studies have shown that the formation of uterine leiomyoma cells may be due to mutations in certain genes, and abnormal proliferation of ovarian hormones stimulate the result of HJ. Animal was found in monkeys and mice are abundant in the uterus IGF-I mRNA in the expression of its receptor, estrogen can increase the expression of IGF mRNA Yi-Gong 8 times synergistic effect of progesterone in the human, IGFs right ovarian steroids promote the synthesis of hormones, estrogen and progesterone resulted in higher uterine fibroids the occurrence and development. However, the results of this study show that the secretion of uterine leiomyoma cells and proliferation of IGF-IR expression of no significant difference in the number of cases may be less concerned with the sample. IGFs and the relationship of hormone levels between the control and the binding protein remains to be studied further.

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