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Carmofur with doxorubicin and cyclophosphamide combination chemotherapy in advanced breast cancer

OO4-0242 (2003) 05-0309-01 acetabular our hospital from February 2001 to December 2002 Xq35 routine Mo fluorine-based combination chemotherapy in advanced breast cancer were observed. 1 Materials and methods Clinical data: 35 patients were female, aged 34 to 62 years old and leaves an age of 45.7 years of age, physical status score of> 60 points, the pathological diagnosis of 19 cases of invasive lobular carcinoma ,[link widoczny dla zalogowanych], 14 cases of invasive ductal carbuncle, medullary paralysis in 2 cases, both recurrence and metastasis in patients with late Lang, towel local lymph node metastasis in 18 cases, 1 case of liver metastasis, lymph node metastasis in 4 cases with lung,[link widoczny dla zalogowanych], lymph nodes in 3 cases with liver metastasis lymph nodes in 10 cases with bone metastasis. Treatment programs: Do fluoride (HCFu) L_1 service-based, each 200mg, 3 times a day, and even served d1 ~ 14 days, the first day while giving doxorubicin fADM) 30mg/rn, cyclophosphamide (CTX) 500mg / 111z infusion, supplemented antiemetic ondansetron. Objective of all patients before chemotherapy were observed. These programs every 3 to 4 weeks for one cycle every two cycles of chemotherapy patients after completion of a comprehensive examination, including physical examination, blood, liver and kidney function, chest X ray, chest CT, abdominal B ultrasound, bone scan ECT. Response Evaluation Criteria: objective response evaluation criteria with reference to WHO standardized, effective complete remission (CR), partial remission (PR), stable (SD), progress fPD), all patients were kept of the boil 2 cycles after the end of the fourth week According to chest x-chip combination of physical examination and chest CT scans evaluated. Adverse reactions observed: during chemotherapy A1 ~ 2 times a week routine, weekly review of liver and kidney function after chemotherapy and after chemotherapy documented adverse reactions, adverse reactions were evaluated using WHO (1979) of dividing the standard anticancer drug toxicity, according to anti- Ma varying degrees, each side is divided into 5 grades. 0 cut for the toxic reaction, I class as the most mild reaction. Ⅳ grade for the most severe reaction. 2 results of efficacy: 35 cases in the wood, PR18 cases, SD14 cases, PD3 cases, the total efficiency of 51.41%. . Received date :2003-03 A I7: Revised :2003-04-24 Chinese Journal of Cancer Volume 12, 2003, No. 5 and effect relationship between the metastatic sites: 18ffd effective are towels, as only 15 cases of lymph node metastasis, 1 cases of liver metastasis alone, 2 cases with bone metastasis lymph nodes, bone metastasis, pain relief, but the bone did not change significantly, with liver and lung lymph node metastasis poorer treatment outcomes. Adverse reactions: the treatment of this group, 33 cases of patients with varying degrees of bone marrow suppression, to leukopenia, followed by 21 cases are gastrointestinal reactions, can be controlled by symptomatic treatment. Frequent urination accompanied by fever and some people after stopping 『3 {immobility of advanced metastatic breast cancer treatment to discuss playing the main purpose is to alleviate symptoms and extend survival of high-quality K I11. Mo fluoride is 5 a Fu series by the third generation of anti-metabolism drugs swollen. Gok slowly through the water in the body release f ¨ 5 Fu played a strong anti-tumor effect,[link widoczny dla zalogowanych], Bomo fluoride for most solid tumors and the tumors were strongly inhibited by warm water, and 5-Fu with the cycle of a specific drug, major role in the cell S, and S phase in tumor cells generally less than 20%,[link widoczny dla zalogowanych], the flash of the sequential oral Carmofur longer tumor doubling time officials have a positive meaning 瀹 treatment. Bu the drug to some extent, a continuous intravenous infusion of 5 to simulate the role of Fu. However, its characteristics and metabolic mechanisms are not identical with the 5 a Fu, continuous long-term maintenance of oral Carmofur blood concentration of drug exposure to tumor cells and to overcome the high-dose chemotherapy in patients with side effects, to ensure that our hospital for the primary treatment Hospital admitted more patients with advanced cancer, and limited financial resources, this group of patients who were already over the line or first-line adjuvant therapy for more than one year after treatment, recurrence or metastasis of advanced breast cancer patients. The oral Carmofur based combination chemotherapy, in 3 cases (visceral metastases) disease progression, the rest were controlled and partial remission, there are still 51-41% of efficiency, Ming Ding improve the quality of life of patients and prolong the survival and economic, convenient, easy-to-be patients and the 5 Carmofur a Fl】 resistant tumor cells also has anti-tumor effect in this group results also suggest HCFU part of advanced breast cancer who have different raise mussels. Its effect on the local lymph node metastasis is better, while the effect of poor internal organs metastasis

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