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Ifosfamide Combined treatment of relapsed or resistant effect of gynecological malignancies

Combined chemotherapy -resistant patients also responded to J. It can be used in conventional chemotherapy drug treatment failure patients. Resistance of the 28 cases of gynecological malignancies , the application 721 * IFO based combination chemotherapy , cR7 cases of PR11 , the total effective rate 6I%, and reported similar, but better than other domestic programs without IFO efficacy of combination chemotherapy . The group of recurrent squamous cell carcinoma and ovarian serous better efficacy , respectively 71.4 % (5 / 7), were higher than reported ),[link widoczny dla zalogowanych], and reported similar J. other types of cases, less easy to analyze . IFO major toxicity was myelosuppression , mainly by leukopenia ,[link widoczny dla zalogowanych], leukopenia 40% of the group , which Ⅲ, Ⅳ degree of reaction of 14.3 % (4 / 2 Cool

required granulocyte colony stimulating factor G-CSF treatment. and give bed isolation, antibiotics to prevent infection. followed by platelets , Ⅲ, Ⅳ degree of reaction of 21.4% (6 / 28 .) accounted for 21 reduction of whole blood .4 % (6 / 2 Cool

. Some patients need to lose a few times and transfusion of fresh whole blood cells or platelets from the blood component therapy, can back up to normal range, does not affect the course of treatment . gastrointestinal symptoms with varying severity to be Use of a serotonin receptor 5 antagonistic agents and dexamethasone treatment. its toxicity can be tolerated , as reversible . hair loss more severe , accounting for 28.5% , after stopping can regenerate. this group of heart,[link widoczny dla zalogowanych], liver, Renal toxicity was mild . with hydration , diuretic and application of protective agents of urinary tract , no cases of hematuria and bladder inflammation . no severe fever and infection . This group showed that , IFO combined in the treatment of gynecological malignant tumor recurrence and drug resistance is effective and . hematopoietic system and gastrointestinal tract reaction heavier,[link widoczny dla zalogowanych], but the timely and effective symptomatic treatment, can be controlled , and the reactions are reversible. 【
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