Newly Discovered Biomarker Predicts Cancer Growth

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Newly Discovered Biomarker Predicts Cancer Growth,[link widoczny dla zalogowanych]
One of the most common questions cancer patients ask their doctors is: has the disease been contained or will it spread. A recent study by U.S. and Chinese researchers may help provide clues. The scientists examined genetic material from certain cancerous tumors and found that when high levels of a particular protein were present, there was a strong likelihood that these cancers would spread within two years.
The source of this discovery was among populations in Asia,[link widoczny dla zalogowanych], where Hepatitis B and liver cancer are prevalent. The World Health Organization estimates in Asia,[link widoczny dla zalogowanych], liver cancer caused by Hepatitis B is one of three major causes of death in men and a major cause in women.
One fourth of the two billion people worldwide infected with the Hepatitis B virus eventually develop liver cancer and die.Scientists in Hong Kong had been studying samples of liver tumor cells and found that some of the cells contained high levels of a variant of the protein Carboxypeptidase E or CPE.
At the same time, scientists at the National Institute of Child Health and Human Development just outside Washington,[link widoczny dla zalogowanych], D.C. were also studying CPE and also identified the same variant,[link widoczny dla zalogowanych], now called CPE-Delta N. "We found that what's in cancer cells is in fact this variant form and so there we got together and [began] exploring this protein as this cancer protein," said Dr. Peng Loh,[link widoczny dla zalogowanych], a neuro-endocrinologist at the National Institute.
The scientists in Washington injected tissue from the Hong Kong liver samples into mice and confirmed that when CPE-Delta N was present,[link widoczny dla zalogowanych], there was a strong likelihood the cancer would metastacize, or spread, within two years. CPE-Delta N has also been identified in cancers of the head and neck, colon, and breast. Preliminary tests indicate it may also be present in thyroid cancer.
In all,[link widoczny dla zalogowanych], Dr. Loh says there could be as many as 14 types of cancer where CPE-Delta N is found. "So we're very careful to say that each one has to be tested in its own right,[link widoczny dla zalogowanych], but I think that it looks like it might cover quite a few," he said.
The researchers say the discovery could change treatment options for patients, especially those identified as having Stage I or II cancer and who carry CPE-Delta N."We feel that those are the ones that we can help the most,[link widoczny dla zalogowanych], because they were the ones who were told most likely you won't get recurrence,[link widoczny dla zalogowanych], so let's not treat," Dr. Loh said. "If we catch those, we have saved some people's lives."
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